Innovations in High Blood Pressure Intervention Benefit Patients with Resistant Hypertension

Breakthrough device-based therapies offer new hope for patients unresponsive to conventional treatments.

The Paradise™ Ultrasound Renal Denervation (uRDN) system is a groundbreaking advancement in hypertension management, particularly for patients whose high blood pressure remains uncontrolled despite medications and lifestyle changes. Developed by Recor Medical, this minimally invasive device-based therapy uses 360-degree ultrasound energy to target and silence the overactive sympathetic nerves surrounding the renal arteries, a key contributor to elevated blood pressure. What sets the Paradise system apart is its unique HydroCooling™ technology, which safeguards the renal artery wall during the procedure by circulating sterile water through the balloon catheter—ensuring precision, safety, and comfort for patients.


The Paradise uRDN procedure is typically completed in under an hour and does not rely on patient adherence to daily medication, making it an ideal adjunctive option for those struggling with resistant hypertension. Administered in a hospital setting, the treatment delivers two to three brief doses of ultrasound, effectively reducing blood pressure across the full 24-hour cycle. Supported by strong clinical evidence—including three randomized, sham-controlled trials—the system has demonstrated lasting reductions in blood pressure and a favorable safety profile. Recor Medical’s ongoing GPS Post-Approval Study in 1,000 patients across the U.S. further aims to validate real-world effectiveness and long-term benefits.


Hypertension is a global public health crisis, often undiagnosed and poorly controlled, contributing to strokes, heart attacks, kidney disease, and premature death. With over 1.3 billion people affected worldwide and a significant portion failing to achieve blood pressure targets, innovation in treatment is vital. The Paradise uRDN system offers new hope for a difficult-to-treat patient population, representing a major leap forward in cardiovascular risk reduction. As awareness grows through initiatives like World Hypertension Day, such innovative solutions can bridge critical treatment gaps—empowering patients and providers to better manage hypertension and extend healthier lives.


MedTech Spectrum's Summary
 
Innovative Ultrasound-Based Therapy: The Paradise™ uRDN system is the first-of-its-kind treatment using 360-degree ultrasound energy to safely and effectively silence overactive sympathetic nerves in the renal arteries—targeting a root cause of resistant hypertension.
 
Minimally Invasive and Medication-Independent: This outpatient procedure offers a non-pharmaceutical solution for patients whose blood pressure remains uncontrolled despite multiple medications, with the added benefit of not relying on patient adherence to daily drugs.
 
Clinically Proven and Endorsed: Backed by multiple randomized, sham-controlled trials and endorsed by major medical societies, the Paradise system has shown lasting blood pressure reductions and represents a critical advancement in addressing one of the leading global health risks.