Bruker’s unveiling of the proteoElute™ nanoLC system and PepSep® Advanced nLC columns at the 73rd ASMS Conference marks a significant step forward in ultra-sensitive proteomics. Designed with cutting-edge TwinScape™ technology, ceramic valves, and advanced sample-trapping features, the proteoElute system offers real-time monitoring, enhanced chromatographic stability, and superior sample integrity. This innovation is purpose-built to meet the rigorous demands of next-generation proteomics, including single-cell analysis, immunopeptidomics, and microbiome metaproteomics—critical fields for advancing biological discovery and clinical research.

The new PepSep Advanced columns are engineered to deliver sharper peaks, improved separation, and increased identification rates for both peptides and proteins. Benchmark studies report up to 20% improvement in peptide identifications and consistent 10% gains in protein identifications, making them a go-to choice for high-resolution and reproducible chromatography. The flexibility of the columns, combined with CaptiveSpray Ionization (CSI) technology, allows labs to extend column lifespan cost-effectively, especially beneficial for high-throughput workflows and low-input sample analysis.

Together, these integrated technologies from Bruker are redefining what’s possible in omics research. With enhanced robustness, minimized carryover, and scalable performance, researchers gain the confidence and precision necessary to explore complex biological systems. The proteoElute and PepSep combination is a powerful, plug-and-play solution that accelerates discovery, drives deeper insights, and supports the growing needs of the global scientific community—pushing proteomics to the forefront of innovation.